Providing guests with cars for rent, Casa Domenico Hotel Valletta is within 3 km of Inquisitor's Palace. Located just near Baroque churches, this guest house also offers proximity to the compact public park "Lower Barrakka Gardens".

The accommodation is about 10 km from Malta International airport and within 5 minutes' drive of such cultural venues as National Museum of Fine Arts. The Renzo Piano–designed City Gate in Valletta is not so far from the hotel. The Point Mall lies about a 5-minute ride from the property. Camarata bus stop is located 5 minutes away from Casa Domenico Hotel.

Bathroom comforts include a hairdryer and towels, and such essentials as a separate toilet and a shower.

Guests can enjoy European cuisine at La Giara, situated only a short stroll from this property.